Twitter is really focused and targeted. And you can use its search function to find members according to various criteria. Say you want to find people to connect with in your city. You can go to the advanced search form and specify a location along with other criteria.
Or you can just use the basic search function and type in one location keyword and another one or more keywords and you'll get some good results. One search that works well is a city name along with "recommend". You'll get a whole bunch of people who are obviously presently in a particular location and hoping for some good advice on which are the best local bars, cafes and restaurants, etc.
This gives you an opportunity to tweet about your location. And those particular tweets can get found by others seeking local tweeps to follow. Needless to say, those people who are asking for the advice will appreciate it, too. Do this regularly and you'll get some local click-throughs.
You can also use Twitter search with website search engine optimization in mind. If you do a location search along with keywords like "blog", "blogger", "webmaster", and "website" you'll find people with a strong online presence. You can interact with them and build up a bit of a rapport. Eventually this is sure to generate the odd link back to your website or blog. These links are doubly powerful because not only are they one way, they are also very geo-targeted.