A recent example: With the Australian election campaign now in full swing, people are Googling like crazy for opinion and information on it. Of course, they often search for the names of politicians. With this in mind, I wrote a post on my humor and opinion blog about a recent event involving Mark Latham and Julia Gillard. I put their two surnames in the title. Just as I'd hoped, I managed to jag a first page listing (just) for searches for "Gillard+Latham".
I haven't had a flood of hits, but visitors from this search are trickling in consistently. So, don't be afraid to trust your gut in keyword selection, particularly when there's a lot of interest around your chosen subject.